Variable |
|
Total |
Follow up group |
Delayed excision group |
p-value |
---|---|---|---|---|---|
Case | 102 | 84 | 18 | ||
Patient | 90 | 73 | 17 | ||
Age (yr), mean (range) | 46.4 (23-80) | 46.5 (23-80) | 45.8 (37-70) | 0.784 | |
Follow up duration (mo), median (range) | 18.6 (6.1-120.9) | 20.0 (6.1-120.9) | 15.5 (6.7-104.4) | 0.276 | |
Initial tumor size (cm) | 0.79 ± 0.36 | 0.75 ± 0.31 | 0.94 ± 0.50 | 0.019 | |
Last tumor size (cm) | 0.73 ± 0.50 | 0.66 ± 0.42 | 1.04 ± 0.69 | 0.003 | |
Percent change in tumor size (%) | +0.22 ± 61.6 | −4.40 ± 59.6 | +21.8 ± 67.4 | 0.101 | |
Previous IDP history* (patient; No. %) | 0.413 | ||||
No | 63 (70.0) | 53 (72.6) | 10 (58.8) | ||
Yes | 27 (30.0) | 20 (27.4) | 7 (41.2) | ||
Tumor location† (case; No. %) | 0.494 | ||||
Central | 85 (83.3) | 71 (84.5) | 14 (77.8) | ||
Peripheral | 17 (16.7) | 13 (15.5) | 4 (22.2) | ||
BIRADS at initial US (case; No. %) | 0.186 | ||||
C3 | 20 (19.6) | 14 (16.7) | 6 (33.3) | ||
C4a | 79 (77.5) | 68 (81.0) | 11 (61.1) | ||
C4b | 3 (2.9) | 2 (2.4) | 1 (5.6) | ||
Multiplicity‡ (patient; No. %) | 1.000 | ||||
Solitary | 73 (81.1) | 60 (82.2) | 13 (76.5) | ||
Multiple | 17 (18.9) | 13 (14.4) | 4 (23.5) | ||
Number of CNB cores (case; No. %) | 0.305 | ||||
≤3 | 5 (4.9) | 5 (6.0) | 0 | ||
4 | 80 (78.4) | 66 (78.6) | 14 (77.8) | ||
5 | 15 (14.7) | 12 (14.3) | 3 (16.7) | ||
≥6 | 2 (2.0) | 1 (1.2) | 1 (5.6) | ||
Symptom (case; No. %) | 0.034 | ||||
No symptom | 84 (82.4) | 69 (82.1) | 15 (83.3) | ||
Palpable mass | 4 (3.9) | 3 (3.6) | 1 (5.6) | ||
Serous nipple discharge | 7 (6.9) | 7 (8.3) | 0 | ||
Bloody nipple discharge | 3 (2.9) | 3 (3.6) | 0 | ||
Breast pain | 2 (2.0) | 0 | 2 (11.1) | ||
Palpable mass & serous nipple discharge | 2 (2.0) | 2 (2.4) | 0 | ||
Personal history of breast cancer§ (patient; No. %) | 0.583 | ||||
No | 86 (95.6) | 69 (94.5) | 17 (100) | ||
Yes | 4 (4.44) | 4 (5.5) | 0 | ||
Family history of breast cancerII (patient; No. %) | 0.587 | ||||
No | 84 (93.3) | 67 (91.8) | 17 (100) | ||
Yes | 6 (6.67) | 6 (8.2) | 0 |
CNB=core needle biopsy; IDP=intraductal papilloma; BI-RADS=breast imaging reporting and data system.
* IDP diagnosis by CNB, surgical excision or vacuum-assisted excision in ipsilateral breast, prior or concurrent;
Variable |
Previous IDP history* |
Tumor location† |
Multiplicity‡ |
|||||||
---|---|---|---|---|---|---|---|---|---|---|
|
|
No |
Yes |
p-value |
Central |
Peripheral |
p-value |
Solitary |
Multiple |
p-value |
Follow up group | n=84 | n=57 | n=27 | n=71 | n=13 | n=63 | n=21 | |||
Initial tumor size (cm) | 0.75 ± 0.31 | 0.78 ± 0.33 | 0.67 ± 0.25 | 0.120 | 0.77 ± 0.31 | 0.62 ± 0.25 | 0.117 | 0.76 ± 0.32 | 0.71 ± 0.26 | 0.530 |
Last tumor size (cm) | 0.66 ± 0.42 | 0.71 ± 0.46 | 0.57 ± 0.32 | 0.171 | 0.66 ± 0.42 | 0.67 ± 0.43 | 0.946 | 0.66 ± 0.44 | 0.67 ± 0.37 | 0.906 |
% change in tumor size (%) | -4.40 ± 59.6 | -4.12 ± 61.0 | -5.02 ± 57.9 | 0.949 | -7.92 ± 58.8 | +14.7 ± 63.1 | 0.210 | -7.36 ± 58.1 | -4.43 ± 64.8 | 0.436 |
Trend of tumor change (No. %) | 0.985 | 0.017 | 0.491 | |||||||
Decreased or no change | 59 (70.2) | 40 (70.2) | 19 (70.4) | 54 (76.1) | 5 (38.5) | 43 (68.3) | 16 (76.2) | |||
Increased | 25 (29.8) | 17 (29.8) | 8 (29.6) | 17 (23.9) | 8 (61.5) | 20 (31.7) | 5 (23.8) | |||
|
||||||||||
Delayed excision group | n=18 | n=10 | n=8 | n=14 | n=4 | n=14 | n=4 | |||
|
||||||||||
Initial tumor size (cm) | 0.94 ± 0.50 | 0.89 ± 0.55 | 1.0 ± 0.47 | 0.505 | 0.99 ± 0.55 | 0.78 ± 0.28 | 0.783 | 0.93 ± 0.51 | 0.98 ± 0.55 | 0.580 |
Last tumor size (cm) | 1.04 ± 0.69 | 1.10 ± 0.61 | 0.98 ± 0.82 | 0.714 | 1.05 ± 0.75 | 1.03 ± 0.49 | 0.951 | 1.09 ± 0.73 | 0.90 ± 0.58 | 0.649 |
% change in tumor size (%) | +21.8 ± 67.4 | +45.5 ± 75.2 | -7.67 ± 44.5 | 0.097 | +19.5 ± 64.3 | +30.1 ± 87.8 | 0.791 | +25.0 ± 58.5 | -11.0 ± 103.4 | 0.727 |
Trend of tumor change (No. | %) | 0.367 | 1.000 | 1.000 | ||||||
Decreased or no change | 10 (55.6) | 5 (50.0) | 5 (62.5) | 8 (57.1) | 2 (50.0) | 8 (57.1) | 2 (50.0) | |||
Increased | 8 (44.4) | 5 (50.0) | 3 (37.5) | 6 (42.9) | 2 (50.0) | 6 (42.9) | 2 (50.0) |
Variable |
|
Final pathology after excision |
||
---|---|---|---|---|
Benign | Upstaged | p-value | ||
Case | 14 | 4 | ||
Patient | 13 | 4 | ||
Age (yr), mean (range) | 43.9 ± 6.26 | 52.8 ± 15.2 | 0.089 | |
Follow up duration (mo), median (range) | 15.5 (10.3-41.4) | 19.0 (6.7-104.4) | 0.158 | |
Initial tumor size (cm) | 0.93 ± 0.51 | 0.98 ± 0.55 | 0.580 | |
Last tumor size (cm) | 0.94 ± 0.75 | 1.40 ± 0.18 | 0.254 | |
Percent change in tumor size (%) | +10.4 ± 61.2 | +62.0 ± 82.3 | 0.185 | |
Reason of excision (case; No. %) | 0.213 | |||
Size increase | 3 (21.4) | 3 (75.0) | ||
Still suspicious sonographic finding | 8 (57.1) | 1 (25.0) | ||
Patient’s preference | 3 (21.4) | 0 | ||
Previous IDP history* (patient; No. %) | 0.588 | |||
No | 7 (53.8) | 3 (75.0) | ||
Yes | 6 (46.2) | 1 (25.0) | 0.197 | |
Tumor location† (case; No. %) | ||||
Central | 12 (85.7) | 2 (50.0) | ||
Peripheral | 2 (14.3) | 2 (50.0) | ||
BIRADS at last US (case; No. %) | 0.664 | |||
C3 | 3 (21.4) | 0 | ||
C4a | 11 (78.6) | 4 (100) | 0.197 | |
Multiplicity‡ (patient; No. %) | ||||
Solitary | 11 (84.6) | 2 (50.0) | ||
Multiple | 2 (15.4) | 2 (50.0) | ||
Symptom (case; No. %) | 0.598 | |||
No symptom | 11 (78.6) | 4 (100) | ||
age (yr), mean (range) | 1 (7.1) | 0 | ||
Nipple discharge | 0 | 0 | ||
Ipsilateral breast pain | 2 (14.3) | 0 | NA | |
Personal history of breast cancer§ (patient; No. %) | ||||
No | 13 (100) | 4 (100) | ||
Yes | 0 | 0 | NA | |
Family history of breast cancerII (patient; No. %) | ||||
No | 13 (100) | 4 (100) | ||
Yes | 0 | 0 |
IDP=intraductal papilloma; BIRADS=breast imaging reporting and data system; CNB=core needle biopsy; NA=not available.
* IDP diagnosis by CNB, surgical excision or vacuum-assisted excision in ipsilateral breast, prior or concurrent;