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Journal of Breast Disease > Volume 12(1); 2024 > Article
Journal of Breast Disease 2024;12(1): 1-11. doi: https://doi.org/10.14449/jbd.2024.12.1.1
Systemic Treatment After Locoregional Recurrence in Breast Cancer: A Review
Min Kyoon Kim, M.D., Ph.D.
Department of Surgery, Chung-Ang University College of Medicine, Seoul, Korea
Corresponding Author: Min Kyoon Kim ,Tel: +82-2-6299-1562, Fax: +82-2-6299-1545, Email: minkyoon96@cau.ac.kr
Received: June 7, 2024    Accepted: June 19, 2024
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ABSTRACT
Locoregional recurrence (LRR) in breast cancer poses significant challenges due to its association with biologically resistant disease and a high likelihood of concurrent occult systemic disease. Despite advancements in local and systemic therapies, LRR affects a substantial percentage of patients, leading to poorer prognosis compared to those with primary breast cancer. Therefore, a comprehensive review of systemic treatment strategies following LRR is warranted to address the gaps in our understanding and improve patient outcomes. This review explored factors influencing the prognosis of breast cancer LRR. In particular, we evaluated the benefits of systemic treatment options post-resection and proposed an optimal treatment algorithm.
Keywords: Breast neoplasms | Chemotherapy | Drug resistant | Recurrence | Treatment switching
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