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Journal of Breast Disease > Volume 7(2); 2019 > Article
Yun, Kim, Lee, Lee, Kim, Chung, Ko, Son, and Ahn: Long-term Follow-up of Pure Ductal Carcinoma in situ after Breast-Conserving Surgery



Ductal carcinoma in situ (DCIS) is a high-risk disease for the development of invasive tumors. Although it is associated with excellent prognosis, many patients undergo extensive treatment with surgery, radiation, and endocrine therapy. This study evaluated the clinical and pathologic factors associated with invasive recurrence, particularly locoregional, distant disease after breast-conserving surgery (BCS).


This study included 431 patients diagnosed with pure DCIS after BCS between January 2000 and December 2008. The clinicopathological characteristics, margin status, adjuvant therapy, and duration of endocrine therapy were evaluated in hormone receptor-positive DCIS patients.


The median duration of follow-up was 115 months. During this period, 37 cases (8.5%) of recurrence were observed (12 in situ and 23 invasive recurrence and 2 unknown cases). There was no distant metastasis as first event. Similarly, none of the initial in situ recurrence cases developed distant metastasis while eight (32%, 8/23) developed distant metastasis after invasive recurrence. Overall recurrence was associated with young age (≤40 years) (HR: 3.60, 95% confidence interval [CI]: 1.77–7.32) and hormone receptor negativity (HR: 3.33, 95% CI: 1.52–7.29). Invasive local recurrence was independently associated with young age (≤40 years) (HR: 3.86, 95% CI: 1.50–9.96), high nuclear grade (HR: 4.46, 95% CI: 1.62–12.27) and omission of adjuvant radiotherapy (HR: 6.45, 95% CI: 1.82–22.82). Notably, duration of endocrine treatment among the hormone receptor positive patient group, was numerically shorter for recurred patients, though not statistically significant.


Young age, high nuclear grade and absence of adjuvant radiotherapy were independently associated with an increased risk of invasive recurrence. Moreover, invasive locoregional recurrence as a first event was associated with worse outcomes, yet in situ recurrence didn’t affect overall survival. Further studies with larger sample sizes are warranted to confirm the prognostic indicators of recurrence and the optimal strategy for adjuvant therapy in this setting.


Ductal carcinoma in situ (DCIS) of the breast, characterized by the proliferation of presumably malignant epithelial cells within the mammary ductal system, represents a heterogeneous group of neoplasias with differing histology and biology. DCIS is frequently detected in screening mammography. Recently, the incidence of DCIS of the breast has increased worldwide [1]. In Korea, the number of newly diagnosed DCIS patients has increased continuously, with an 8.7-fold increase in the incidence rate between 1999 and 2014 [2]. The National Comprehensive Cancer Network (NCCN) guidelines for the treatment of DCIS recommend excision of all disease to negative margins through mastectomy or breast-conserving surgery (BCS) with or without radiotherapy [3]. Local recurrence (LR) rates after BCS with radiotherapy are higher than those observed after mastectomy (10–15% vs. 1–2%, respectively) due to remnant ipsilateral breast tissue after BCS. However, this has not translated to a difference in breast cancer-specific mortality [4,5]. Thus, the proportion of patients receiving BCS has increased steadily, raising concerns regarding LR. LR remains a clinical concern because the invasiveness of this recurrence is associated with mortality [6-9]. Identifying patients who are at a high risk for LR is crucial. This study aimed to identify the predictors of LR after BCS.


Study population

We retrospectively reviewed the records of 431 consecutive patients diagnosed with pure DCIS who underwent BCS at Asan Medical Center, Seoul, Korea between January 1, 2000 and December 31, 2008. Data were obtained from the Breast Cancer Center database of Asan Medical Center. The study protocol was approved by the Institutional Review Board of Asan Medical Center (IRB No. 2016-0229). Patients with a history of invasive cancer treated previously or with simultaneous contralateral invasive tumors were excluded. Demographic, pathologic, treatment, and follow-up variables were analyzed including- tumor size, nuclear grade, comedo necrosis, multifocality, hormone receptor and human epidermal growth factor receptor 2 (HER2) status (positive or negative) by immunohistochemical (IHC) staining, and microscopic resection margin. Further fluorescence in situ hybridization for HER2 scores of 2+ by IHC staining was not done. Surgical margin was defined as “negative” if there was no ink on the tumor. Nuclear grades were analyzed using a dichotomous scale (low and high).
The follow-up evaluations included a physical examination and mammography with/without ultrasound every 6 months. Ultrasonography-guided core needle biopsy or fine-needle aspiration was performed for pathological confirmation for suspicious lesions. An ipsilateral breast tumor recurrence (IBTR) was defined as a recurrent in situ or invasive carcinoma occurring after BCS in either the skin or parenchyma of the ipsilateral breast. Regional failure was defined as recurrence in the regional lymph nodes including the ipsilateral axillary nodes, and supraclavicular neck nodes without any evidence of IBTR.

Statistical analysis

All statistical analyses were performed using IBM SPSS Statistics for Windows, version 22.0 (IBM Corp., Armonk, USA). The non-recurrence and recurrence groups were compared using Chi-square or Fisher’s exact tests for categorical data and Student’s t or Mann–Whitney U tests for continuous data with non-normal distributions. The rates of recurrence-free survival were estimated using the Kaplan–Meier method and the significance of the differences was determined using log-rank tests. Variables identified as likely to be associated with disease-free survival (p<0.2) via univariate analysis were included in a multivariate Cox proportional hazards regression model. The multivariate analysis attempted to identify the predictors of LR in patients with DCIS. The adjusted hazard ratios (HRs), and 95% confidence intervals (CIs) were calculated. P-values <0.05 denoted statistical significance.


Clinicopathological characteristics

Total of 431 patients diagnosed with pure DCIS were treated with BCS. The median duration of follow-up after surgery was 115 months (range: 3–195 months). Median age at diagnosis was 47 years (range: 19–82 years). Following BCS, adjuvant radiotherapy was performed in 401 patients (93%). Permanent involvement of the resection margins was noted in 38 cases (8.8%) and all underwent subsequent radiotherapy. Overall recurrence were reported among 37 patients (8.6%) with 5-year and 10-year total recurrence rates of 4% and 6.5%, respectively. Among the 37 patients with recurrence, five had regional lymph node metastasis and two had concurrent IBTR. While distant metastasis was not observed as the first event, 8 patients had distant metastasis after locoregional event. Fifteen patients developed subsequent contralateral breast tumors. Characteristics of the study population are summarized in Table 1.

Factors associated with Loco-regional recurrence (LR)

Of the 37 patients who developed recurrence during the follow-up period, 12 (32.4 %) and 23 (62.2 %) developed non-invasive and invasive recurrence respectively with 2 unknown cases. In univariate analysis, age, hormone receptor status and IHC-defined subtype were associated with overall recurrence while presence of comdo necrosis, positive resection margin, nor adjuvant radiotherapy were not (Table 2). Younger age (≤40 years) (HR: 3.60, 95% CI: 1.77–7.32) and hormone receptor negativity (HR: 3.33, 95% CI: 1.52–7.29) were independently associated with overall recurrence in multivariate analysis (Table 3). When excluding in situ recurrence, younger age, higher nuclear grade, IHC-defined subtype and omitting radiotherapy were associated with invasive recurrence in univariate analysis (Table 2). The Cox proportional hazards model showed age ≤40 years (HR: 3.86, 95% CI: 1.50–9.96), high nuclear grade (HR: 4.46, 95% CI: 1.62–12.27), and absence of radiotherapy (HR: 6.45, 95% CI: 1.82–22.82) to be independently associated with greater risk of invasive recurrence (Table 3). The Kaplan–Meier curves demonstrating the magnitude of these variables on the rates of 10-year recurrence-free survival are shown in Figure 1.
After excluding 113 patients with unknown HER2 status, the remaining 318 patients were classified according to the following four phenotypes: HRpositive/HER2negative, HRpositive/HER2positive, HRnegative/HER2positive and triple negative subtypes. IHC-defined subtype was associated with both overall and invasive local recurrence in univariate analysis (Table 2, p=0.008, p=0.024). However, the subtype was not significantly associated with neither overall and invasive recurrence in multivariate analysis.
Subgroup analysis performed in patients with positive hormone receptor status showed that 79.4% (269/339) received endocrine therapy, and 71.4% (192/269) completed endocrine therapy for 5 years while 28.6% discontinued. Recurrence in the ipsilateral breast or regional lymph nodes was observed in 23 patients, while contralateral breast cancers were observed in 14 patients among the 339 hormone receptor positive patients. The mean duration of endocrine therapy was shorter in patients with a breast event versus that in patients without (31.3 ± 27.6 vs. 41.1 ± 25.4 months, respectively); however, this difference was not statistically significant (p=0.075).
All locoregional recurrence cases undergone surgical excision. Among 23 invasive recurrence cases, 10 patients have undergone breast conservation, 11 with salvage mastectomy and 2 with axillary lymph node excision. Subsequent systemic therapy was performed according to the invasive tumor size, hormone receptor and HER2 status.

Distant metastasis and survival after the first recurrence

Metastatic disease or death caused by breast cancer did not occur in any of the 12 patients with non-invasive recurrences. Among the remaining patients, eight (32%, 8/25) developed distant metastasis after first recurrence. Four patients developed bone metastases, 2 patients developed lung metastasis and 1 patient with liver metastasis with distant lymph nodes (one patient with unknown site). The median time from the first recurrence to distant metastasis was 30 (range: 25–61) months. At the last follow-up, seven patients had died due to the disease. The median time from the date of diagnosis of distant metastasis until death was 32 (range: 12–67) months. Breast cancer-specific survival between invasive vs in situ recurrence is displayed in Figure 2.


Previously reported rates of LR ranged between 9% and 21%, with half of the recurrence cases identified as invasive [5,10,11]. In the present study, LR developed as the first event in 37 patients and was invasive in 23 of those (65.7%, 23/35, 2 invasiveness unknown). These lower rates and relatively higher proportion of invasiveness compared to those in other studies are linked to the treatment protocols implemented in Asan Medical Center. Most patients (93%) treated with BCS received radiotherapy. During follow-up, screening via mammography and physical examination were performed biannually on conservatively treated patients in Asan Medical Center. Silverstein et al. [12] reported that the diagnosis of recurrent tumors is more challenging after radiotherapy due to radiotherapy-related fibrosis and scarring which obscure the signs of LR. Moreover, breast density lowers the sensitivity of mammography and studies have shown higher breast density in Korean versus Western women [13]. For patients with dense breasts, the selective use of sonography may be helpful.
In the present study, younger age at diagnosis (≤40 years) was a predictive factor for all types of LR. Invasive breast cancer in younger patients is generally associated with poor biological factors and treatment outcomes. However, such data are currently limited for patients with DCIS. A study investigating the long-term outcomes after BCS followed by definitive breast irradiation in women with asymptomatic DCIS of the breast showed that patients aged ≥50 years at the time of treatment initiation had with lower rates of LR [11]. Although the definition of “young age” is not absolute, relatively younger patients tend to be associated with diseases with more aggressive pathology. Vicini and Recht[14] reported a higher incidence nuclear grade 3 DCIS in patients aged <45 years compared to that in older patients (p=0.003), while necrosis was more common in tumors found in younger patients (p=0.01). In addition, Schouten et al. [15] reported that younger patients (<50 years) with DCIS were treated with mastectomy less frequently compared to older patients (p<0.01). In the present study, younger patients were linked to negative-hormone receptor status. The mean duration of hormone therapy was shorter in patients aged ≤40 years. However, after adjusting for other factors, only age remained significant.
Despite the heterogeneity of DCIS, it may be categorized according to nuclear grade. Numerous studies have shown the association between a high nuclear grade and LR. A population-based study showed that the 10-year actuarial rate of LR was higher in patients with high nuclear grade than that in patients with low or intermediate nuclear grade disease [16]. In addition, the association between nuclear grade and risk of LR was demonstrated in a meta-analysis of 16 trials involving a total of 10,526 women with DCIS [17]. The results showed an increased risk in patients with a higher nuclear grade of DCIS. Low nuclear grades (grades 1-2) and an absence of necrosis were associated with a reduced risk of ipsilateral breast events [18]. The present study showed that high-grade tumors were more likely to recur with an invasive nature compared to intermediate- or low-grade tumors.
Various studies have reported that radiotherapy reduced the incidence of invasive and non-invasive recurrence. The European Organization for Research and Treatment of Cancer (EORTC) trial reported that the use of radiotherapy after excision of DCIS led to a 47% reduction of LR 10 years after treatment. This effect was maintained long-term, with a 48% reduction reported 15 years after treatment [5,7]. In the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-17 trial, a randomized clinical trial with a median follow-up of 17.3 years, radiotherapy reduced the risk of LR by approximately 50% [10]. In another trial with a median follow-up of 12.7 years, the reduction of risk derived from radiotherapy ranged from 30% to 56% [19]. A meta-analysis of randomized trials (including the aforementioned trials) reported a reduced risk of LR after radiotherapy irrespective of the age at diagnosis, tumor size, grade, and margin status [20]. In the present analysis, radiotherapy was associated only with the risk of invasive LR.
The IHC-defined subtype was unavailable in approximately one-quarter of patients included in this study. The low incidence of events did not permit multivariate analysis focusing on invasive IBTR. The rate of recurrence was higher in the HRnegative/HER2positive group despite its small proportion in the study population. Currently, there is limited and conflicting evidence concerning the prognostic significance of molecular phenotypes in DCIS. Williams et al. [21] suggested an association between luminal B, HER-2, and triple-negative DCIS and recurrence compared to that for luminal A DCIS. Other reports confined to invasive breast cancer showed similar results [22]. In contrast, no significant correlation was found between various biological markers and disease recurrence [23,24]. In future studies, determining the molecular phenotype through IHC analysis may be useful in identifying predictive factors.
Based on the NCCN guidelines, patients with a positive hormone receptor status are treated with endocrine therapy. The NSABP B-24 trial showed that the benefits of tamoxifen may be confined to hormone receptor-positive DCIS [25]. Tamoxifen administered as adjuvant therapy after BCS is beneficial in reducing ipsilateral recurrence and contralateral events in ER-positive DCIS patients [19,25]. In the current study, 79.1% of hormone receptor-positive patients received low-dose tamoxifen. However, the results did not show significant effects on ipsilateral recurrence and contralateral events. An additional analysis of adherence to tamoxifen may help explain this discrepancy.
Other risk factors reported in the literature (close or positive margins, comedonecrosis, and/or large tumor size) [11,24,26,27], were not statistically significant in the present study.
This study demonstrated that the incidence of distant metastasis after an initial diagnosis of pure DCIS is rare. In the NSABP B-17 trial, only 6 of the 814 enrolled patients developed metastasis as a first event after treatment with partial mastectomy with or without radiotherapy [28]. Bannani et al. [29] reported distant metastasis in 4 of 218 patients treated with mastectomy for DCIS. The low incidence of distant metastasis restricted further statistical analysis. Interestingly, all patients who developed metastasis after a diagnosis of pure DCIS have intervening invasive locoregional recurrence. In the EORTC 10853 trial, a diagnosis of invasive LR increased the risk of mortality by five-fold compared to that in patients without LR [7]. Romero et al. [6] assessed patient survival in a subgroup of 53 DCIS patients with invasive recurrence. The 10-year breast cancer-specific survival rate was 85%, similar to that of patients with stage IIA disease. Therefore, invasive LR should be prevented. Buist et al. [30] also showed that patients with initial DCIS are associated with substantially higher incidence rates of secondary cancer regardless of initial treatment. Although the 5-year survival rate of DCIS is almost 100%, adherence to surveillance in patients after BCS is crucial for the early detection of invasive LR and secondary cancer.
The present study has several limitations. This was a retrospective study conducted in a single center without centralized pathologic review. The limited number of events in the total DCIS population limited the statistical power of the analysis and subgroup analyses couldn’t be done owing to small numbers.
In conclusion, invasive recurrence after pure DCIS was associated with age at diagnosis, nuclear grade, and adjuvant radiotherapy. Individual evaluation of these prognostic factors may help identify patients requiring active treatment and close monitoring.


The authors declare that they have no competing interests.

Figure 1.
Kaplan-Meier plots showing the effects of variables on (A) recurrence-free survival, (B) invasive recurrence-free survival.
Figure 2.
Kaplan-Meier estimates breast cancer-specific survival according to the type of recurrence.
Table 1.
Clinicopathological characteristics of patients
Variable n = 431
No. (%)
Median age at diagnosis, years (range) 47 (19–82)
Simultaneous bilateral DCIS 7 (1.6)
Resection margin
 Negative 393 (91.2)
 Positive 38 (8.8)
Nuclear grade
 1 81 (18.8)
 2 263 (61.0)
 3 55 (12.8)
 Unknown 32 (7.4)
Comedo necrosis
 Yes 181 (42.0)
 No 162 (37.6)
 Unknown 88 (20.4)
 Positive 323 (74.9)
 Negative 64 (14.8)
 Unknown 44 (10.3)
 Positive 300 (69.6)
 Negative 87 (20.2)
 Unknown 44 (10.2)
 Positive 83 (19.3)
 Negative 235 (54.5)
 Unknown 113 (26.2)
IHC-defined subtype
 HR positive/HER2 negative 224 (52.0)
 HR positive/HER2 positive 53 (12.3)
 HR negative/HER2 positive 30 (7.0)
 Triple negative 11 (2.6)
 Unknown 113 (26.1)
 Yes 401 (93.0)
 No 24 (5.6)
 Unknown 6 (1.4)
Endocrine therapy
 Yes 300 (69.6)
 No 120 (27.8)
 Unknown 11 (2.6)
Event during follow-up
 Recurrence 37 (8.6)
  IBTR only 30
   Non-invasive 12
   Invasive 18
  IBTR+regional failure 3
  Regional failure only 2
  Unknown 2
 Contralateral breast tumor 15 (3.5)
  Non-invasive 7
  Invasive 8

DCIS=ductal carcinoma in situ; ER=estrogen receptor; PR=progesterone receptor; HER2=human epidermal growth factor receptor 2; IHC=immunohistochemistry; IBTR=in-breast tumor recurrence.

Table 2.
Comparison of clinicopathologic characteristics by recurrence status
Characteristic NED Overall recurrence p-value Invasive LR p-value
n = 394 n = 37 n = 21
No. (%) No. (%) No. (%)
Age at diagnosis 0.004 0.012
 ≤ 40 84 (21.3) 16 (43.2) 10 (47.6)
 > 40 310 (78.7) 21 (56.8) 11 (52.4)
HR status 0.010 0.059
 Positive 316 (80.2) 23 (62.2) 14 (66.7)
 Negative 39 (9.9) 9 (24.3) 5 (23.8)
 Unknown 39 (9.9) 5 (13.5) 2 (9.5)
HER2 status 0.129 0.697
 Positive 74 (18.8) 9 (24.3) 3 (14.3)
 Negative 222 (56.3) 13 (35.1) 6 (28.6)
 Unknown 98 (24.9) 15 (40.5) 12 (57.1)
IHC-defined subtype 0.008 0.024
 HRpositive/HER2negative 212 (53.8) 12 (32.4) 5 (23.8)
 HRpositive/HER2positive 51 (12.9) 2 (5.4) 0
 HRnegative/HER2positive 23 (5.8) 7 (18.9) 3 (14.3)
 Triple negative 10 (2.5) 1 (2.7) 1 (4.8)
 Unknown 98 (24.9) 15 (40.5) 12 (57.1)
Radiation therapy 0.135 0.028
 Yes 369 (93.6) 32 (86.5) 17 (81.0)
 No 20 (5.1) 4 (10.8) 4 (19.0)
 Unknown 5 (1.3) 1 (2.7) 0
Resection margin 0.760 1.0
 Free 358 (90.9) 35 (94.6) 19 (90.5)
 Involvement 36 (9.1) 2 (5.4) 2 (9.5)
Parenchymal pattern 0.709 1.0
 1/2 188 (47.7) 18 (48.6) 10 (47.6)
 3/4 163 (41.4) 13 (35.1) 8 (38.1)
 Unknown 43 (10.9) 6 (16.2) 3 (14.3)
Nuclear grade 0.121 0.043
 Low 317 (80.5) 27 (73.0) 14 (66.6)
 High 47 (11.9) 8 (21.6) 6 (28.6)
 Unknown 30 (7.6) 2 (5.4) 1 (4.8)
Necrosis 0.239 0.604
 Absence 152 (38.6) 10 (27.0) 6 (28.6)
 Presence 163 (41.4) 18 (48.6) 9 (42.8)
 Unknown 79 (20.0) 9 (24.3) 6 (28.6)
Microcalcification 0.054 0.36
 Absence 144 (36.5) 21 (56.8) 10 (47.6)
 Presence 204 (51.8) 15 (40.5) 11 (52.4)
 Unknown 46 (11.7) 1 (2.7) 0
Multifocality 0.638 0.356
 No 329 (83.5) 30 (81.1) 16 (76.2)
 Yes 61 (15.5) 7 (18.9) 5 (23.8)
 Unknown 4 (1.0) 0 0
Tumor size (cm) 0.306 0.626
 Mean 1.24 ± 1.15 1.44 ± 1.08 1.36 ± 1.02
 Range 0.10–9.00 0.30–4.80 0.40–4.80

NED=no evidence of disease; LR=local recurrence; HR=hormone recptor; HER2=human epidermal growth factor receptor 2; IHC=immunohistochemistry.

Table 3.
Multivariate analysis of predictive risk factors of local recurrence by Cox proportional hazard model
Variable Overall recurrence
Hazard ratio 95% Confidence interval
Age at diagnosis
 ≤ 40 years (vs. > 40) 3.60 1.77–7.32 < 0.001
HR status
 Negative (vs. Positive) 3.33 1.52–7.29 0.003
Adjuvant RT
 No (vs. Yes) 1.78 0.23–13.49 0.579

Variable Invasive LR
Hazard ratio 95% Confidence interval

Age at diagnosis
 ≤40 years (vs. >40) 3.86 1.50–9.96 0.005
Nuclear grade
 High (vs. Low) 4.46 1.62–12.27 0.004
Adjuvant RT
 No (vs. Yes) 6.45 1.82–22.82 0.004

HR=hormone receptor; RT=radiotherapy; LR=local recurrence.


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